Application

Viral Vectors

Viral vector manufacturing: Mastering complexity to power the future of gene therapy

Viral vector manufacturing: key to successful gene therapy

Viral vector manufacturing sits at the center of gene therapy’s growth, and BSL-2 cleanroom requirements aren’t a box to check, they’re the foundation the process runs on. Germfree builds cleanroom environments that meet those requirements by design, so AAV and lentivirus production can move forward safely and efficiently. It’s specialized work, and our facilities are built specifically for it.

Fit-for-purpose Facilities and Equipment for Viral Vector Manufacturing

Select from a number of application-ready layouts & equipment. If these do not meet your needs, reach out and learn more about our custom solutions.

Mobile

bioGO^®: Mobile cGMP Cleanrooms for Viral Vector Manufacturing

Discover bioGO^® cGMP Mobile Cleanroom trailer, designed to address urgent biopharma manufacturing capacity needs with versatility and adaptability to a range of processes, from cell therapy to sterile fill manufacturing. Perfect for clinical phase or point-of-care manufacturing, and supported by comprehensive services, including design, fabrication, validation, and maintenance.

Germfree’s expertise drives the design and operation of this mobile platform, meeting and exceeding FDA cGMP requirements and industry best practices. Choose bioGO^® for flexible, reliable, and compliant manufacturing solutions to address the biopharma industry’s capacity challenges.

Learn more about our mobile facilities

Germfree has deployed more than 100 mobile cleanrooms globally since 2015
Ideal for advanced therapy manufacturing, including cell and gene therapies
cGMP compliance by design, ISO 7/8 Grade B, C and D, BSL2. BSL3
Supported by comprehensive services, including 24/7 service support, remote monitoring, and preventative maintenance
Rapid deployment in weeks not months; gain access to the clinic sooner
Available for sale or lease

Mobile cGMP Cleanrooms

Germfree’s Mobile cGMP Cleanroom platform supports aseptic processing needs with a flexible, rapidly deployable design.

Key applications:

Cell Therapy

Gene Therapy

Aseptic Filling

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Modular

Modular cGMP Cleanrooms for Viral Vector Manufacturing

Germfree’s prefabricated Modular cGMP Cleanroom facilities support advanced therapy and pharmaceutical production processes, with layout options and mechanical space configurations for a free-standing facility or one inside a shell building. Design, project management, supply chain, commissioning and qualification, and maintenance are handled as one service, start to finish. Germfree’s modular cleanroom facilities are built for flexibility, reliability, and compliance in biopharmaceutical manufacturing.

Learn more about our modular facilities

Onsite in ~ 8 Months for standard platforms
Compliant: US & EU cGMP – BSL2 -BSL3 – ISPE Baselines Guides, ISO14644
Flexible layout configurations based on standard platform technology
High-quality construction by design minimizes risk of contamination
Provided turnkey with comprehensive services, including commissioning and qualification, 24/7 service support, remote monitoring, and preventative maintenance
Can be combined with Pharmaceutical Isolators, RABS, Biosafety Cabinets, Laminar Flow Hoods, Pass-throughs, Gowning Benches and 100% Stainless Steel Casework
Available for sale or lease

Modular cGMP Cleanrooms

Germfree cGMP Modular Cleanroom facilities support both cGMP and cGMP/BSL2 production.

Key applications:

Aseptic Filling

CGT Manufacturing

Viral Vectors

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Equipment

Innovative Aseptic Processing Equipment and PECs

Germfree built its first piece of equipment more than 60 years ago, and every primary engineering control in our current line carries six decades of refinement forward: 100% stainless steel construction, ergonomic design built around the people who use it, and the ability to handle both hazardous and non-hazardous materials. That track record is what a service life measured in decades looks like in practice. Our range covers Pharmaceutical Isolators and Restricted Access Barrier Systems, Laminar Flow Workstations, Biological Safety Cabinets (BSCs), Compounding Aseptic Isolators (CAIs), Compounding Aseptic Containment Isolators (CACIs), Powder Hoods, and Material Pass Throughs. Six decades in, we know what holds up.

Learn more about our equipment

Standard Biosafety Cabinets and Laminar Flow Hoods ship fast
NSF/ANSI49 options available
Innovative touch control interface on some models
100% 304 and 316 L stainless steel construction
Mobile and modular facility integration
Durable and easy to clean, backed by a service life spanning decades

All EQT- Biopharmaceutical Isolators & RABS EQT-Class II Type A2 BSC EQT-Class II Type B2 BSC EQT-Vertical Laminar Airflow Workstation EQT-Horizontal Laminar Airflow Workstation EQT - 100% Stainless Steel Casework EQT-Pass-Through

Pharmaceutical Isolators

Germfree designs and manufactures cGMP-compliant pharmaceutical isolators in the USA, protecting products, personnel, and laboratory processes.

Smarthood™

Smarthood™ is our innovative solution that integrates essential peripherals like touchscreen PCs, cameras, scales, and printers directly into a clean, clutter-free hood, enhancing aseptic technique and streamlining your workflow.

Stainless Steel Laboratory Furniture

Germfree's 100% stainless steel laboratory furniture resists corrosion, rust, and bacterial growth, custom designed for your lab or cleanroom.

Frequently Asked Questions

Explore additional insights

What cleanroom classifications does Germfree support for viral vector manufacturing?

Germfree’s viral vector solutions are built to cGMP compliance by design, spanning ISO Class 7 and 8 (Grade B, C, and D) cleanroom environments with BSL-2 and BSL-3 containment options, so AAV and lentivirus production can meet both biosafety and aseptic processing requirements in a single facility.

What’s the difference between Germfree’s mobile and modular viral vector platforms?

The bioGO® Mobile cGMP Cleanroom is a trailer-based platform that deploys in weeks rather than months, making it suited to clinical-phase or point-of-care manufacturing. The Modular cGMP Cleanroom is a prefabricated, free-standing or shell-building facility that takes roughly eight months to install and is built for larger-scale, longer-term viral vector and advanced therapy production.

Can Germfree’s viral vector facilities support both cell and gene therapy processes?

Yes. Both the mobile and modular platforms are designed for advanced therapy manufacturing, including cell therapy, gene therapy, and aseptic filling applications, and can be combined with Pharmaceutical Isolators, Restricted Access Barrier Systems, Biosafety Cabinets, Laminar Flow Hoods, pass-throughs, gowning benches, and 100% stainless steel casework.

Are Germfree’s viral vector manufacturing facilities available for lease?

Both the bioGO® mobile cleanroom and the modular cleanroom platforms are available for sale or lease, giving manufacturers flexibility to scale capacity to clinical timelines without committing to permanent infrastructure.

What primary engineering controls does Germfree offer for viral vector processing?

Germfree’s PECs, including Pharmaceutical Isolators, Restricted Access Barrier Systems, Laminar Flow Workstations, Biological Safety Cabinets, Compounding Aseptic Isolators, Compounding Aseptic Containment Isolators, Powder Hoods, and Material Pass Throughs, are built in 100% stainless steel and designed to handle both hazardous and non-hazardous materials, drawing on equipment engineering Germfree has refined for over 60 years.

Talk to us about the right solution for your application

When your mission calls for something custom, we deliver.

Some environments can’t take a catalog answer: the one-of-a-kind containment lab, the facility that has to survive shipment by military aircraft, the compounding pharmacy that has to stand up overnight. Tell us the constraints, we’ll build around them.

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