Viruses have evolved over time with specialized mechanisms that transport their genomes inside the cells they infect. Modified viruses are used as viral vectors (delivery mechanisms) in gene therapy, protecting the new gene and delivering it to the target cells. Viral vectors enable target cells to accept and separate the new gene from the virus particle and transport it to the cell nucleus at which time the new gene starts to perform its function. There are several virus types used for manufacturing of viral vectors including adenovirus, adeno-associated, herpes simplex, lentivirus, and retrovirus that can be used to deliver nucleic acids into and thereby alter the genetics of a cell.
Germfree designs and manufactures cleanrooms and biocontainment suites as well as process and biosafety equipment to serve a wide range of biopharmaceutical production needs including monoclonal antibodies, therapeutic proteins, virotherapies, and live virus vaccines.
Germfree’s bioGO biocontainment cleanrooms are pre-designed and adaptive to provide an offsite built, process ready solution for advanced applications, available in 3 primary platform technologies:
Mobile (mobile trailer/vehicle platform) Single Module (self-contained cleanroom module platform) Modular Cleanrooms (integrated, interconnected, multi-module, structural building platform)
Germfree’s advanced process and biosafety equipment is purpose built to meet client user requirements and includes:
Class II Biological Safety Cabinets Cleanroom Pass-throughs Laminar Flow Hoods Restricted Access Barrier Systems (RABS) Aseptic Isolators Dehumidification Chambers Cleanroom Tables, Shelves, and Workstations
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It is the dedication of the Germfree team that enables rapid deployment of critical infrastructure both to cutting edge research facilities and the front lines of global health security