BIOCONTAINMENT SOLUTIONS

Class III Biosafety Equipment

Germfree is internationally recognized as a leading manufacturer of Class III Biological Safety Cabinets. Our Class III Gloveboxes provide containment for diverse research applications in the most advanced ABSL-3, BSL-3 and BSL-4 laboratories. Our Class III BSCs are engineered to exceedingly rigorous standards for work that involves dangerous pathogens or unknown agents. We specialize in the seamless integration of all laboratory components, analytical instruments and process equipment. Choose between Standard and Custom or explore below:

Germfree’s Class III BSCs are engineered with the optimal direct connections to any laboratory equipment, including autoclaves, incubators, and gas decontamination systems. Germfree designs systems that may be configured to keep analytical equipment controls outside of the containment zone. Designed for ergonomics, all products are engineered with the user in mind.

Standard Class III Configurations

Explore our Standard Glovebox options

Standard Glovebox
(SEA)

The SEA-III BSC solves the primary obstacles faced when adding Class III containment to an existing lab, namely space constraints and cost. The SEA III is highly ergonomic Class III Biological Safety Cabinet to work within the constraints of your lab without compromising on features, functionality and user comfort.

PGB-3SS-Staged-scaled-removebg-preview

Portable Glovebox
(PGB)

Germfree’s PGB-III is the first field-deployable containment device that meets all of the requirements for a Class III Biological Safety Cabinet, as well as the standards for a Glovebox by the American Glovebox Society (AGS). Click below to learn more:

SEA Class III BSC Germfree

Custom Glovebox (SEA/PGB)

The custom single or double-sided glovebox meets the needs of laboratories all over the world– featuring a host of options and complete configurability. The SGB III delivers Class III functionality for a variety of applications, fit specifically to your needs. Click below to learn more.

CLASS III GLOVEBOXES

Mobile & Transportable

Germfree makes a complete line of Mobile and Transportable Class III equipment for a wide range of laboratory applications used worldwide. We are the leading innovator of Class III gloveboxes for mobile laboratories and designed the first field-deployable portable unit. Our exhaust air filtration systems are available with HEPA or HEPA/Carbon for either biological or chemical/biological hazards.

Class III For Remote Use

Germfree makes a complete line of Mobile and Transportable Class III equipment for a wide range of laboratory applications used worldwide. We are the leading innovator of Class III gloveboxes for mobile laboratories and designed the first field-deployable portable unit. Our exhaust air filtration systems are available with HEPA or HEPA/Carbon for either biological or chemical/biological hazards.-Portable Glovebox PGB-III -Class III Mobile Installations -Class III Portable Applications -Rapid Containment Kits

  • Germfree’s PGB-III is the first field-deployable containment device that meets all of the requirements for a Class III Biological Safety Cabinet, as well as the standards for a Glovebox by the American Glovebox Society (AGS).

Standard Glovebox

Depending on the specific application and installation, Germfree's standard glovebox, the SEA III, is great choice that can afford flexible mobility and a proven track record of successful implementations. As a standard unit, the SEA III has been overengineered to meet the needs of many applications, delivering on the reliable Germfree name and legacy.

  • The SEA-III BSC solves the primary obstacles faced when adding Class III containment to an existing lab, namely space constraints and cost. Our engineers designed this highly ergonomic Class III Biological Safety Cabinet to work within the constraints of your lab without compromising on features, functionality and user comfort. Learn More

CLASS III GLOVEBOXES

High Containment

Germfree has designed and built specialized Class III glovebox systems for laboratories that are equipped to receive high-risk unknown samples such as chemical and/or biological weapons. These laboratories are operated by the Department of Homeland Security, state and local Public Health Agencies, Police and Fire Departments, and military units of many countries.

High Containment

Decades of experience building equipment for a variety of high containment applications has positioned Germfree to deliver a right-sized solution for your application. Germfree's robust engineering team will work together through your assigned project manager to deliver a custom containment solution, built off decades of containment experience.

  • The Class III BSC can be installed into a diverse range of research environments. For work involving highly infectious microbiological agents, the Class III BSC is a critical lab component. Class III Biological Safety Cabinets provide the primary containment for manipulation of dangerous pathogens in BSL-4 Cabinet Laboratories. Additionally, when installed in BSL-3 labs, these enclosures offer an added level of containment for higher risk work. Class III units are also utilized for handling materials with an unknown risk level in security applications.

Containment Abroad

Germfree's high containment solutions don't solely require advanced laboratories and infrastructure. Designed specifically for use in remote or distaster-stricken locations, Germfree's PGB III is ready for the challenge.

  • Germfree’s PGB-III is the first field-deployable containment device that meets all of the requirements for a Class III Biological Safety Cabinet, as well as the standards for a Glovebox by the American Glovebox Society (AGS).

CLASS III GLOVEBOXES

Aerobiology

Germfree is the industry leader for Class III BSC systems used in aerobiological studies. Our high containment Class III BSC-gloveboxes are integrated with the aerosol generator and animal exposure methods utilized for your applications within Aerobiology Laboratories. Our innovative designs can incorporate animal transfer carts equipped with Rapid Transfer Ports and Class III BSCs to ensure safety for personnel and research animals. Germfree has extensive working relationships with controlled aerosol generator and animal exposure equipment manufactures.

Aerobiology Solutions

Aerobiology labs utilize Class III Biological Safety Cabinets that are built around aerosol generators for work in aerobiological studies. Transfer carts that are equipped with Rapid Transfer Ports and a Class III BSC insure personnel and environmental safety, improve research productivity, as well as provide for animal welfare.

  • Aerobiology processes can be designed to handle multiple species. Specialized aerosol exposure systems are fully integrated into the cabinet, and precisely control the challenge concentration ensuring uniform exposures to achieve consistent research results. Vapor phase generators or other systems provide for ease of decontamination.

Custom Class III Configurations

Explore our Custom Gloveboxes

Purpose Built Class III

Decades of experience building equipment for a variety of high containment applications has positioned Germfree to deliver a right-sized solution for your application. Germfree's robust engineering team will work together through your assigned project manager to deliver a custom containment solution, built off decades of containment experience. Reach out at the link below to get in touch:

  • The Class III BSC can be installed into a diverse range of research environments. For work involving highly infectious microbiological agents, the Class III BSC is a critical lab component. Class III Biological Safety Cabinets provide the primary containment for manipulation of dangerous pathogens in BSL-4 Cabinet Laboratories. Additionally, when installed in BSL-3 labs, these enclosures offer an added level of containment for higher risk work. Class III units are also utilized for handling materials with an unknown risk level in security applications. Learn More

STANDARD & CUSTOM OPTIONS

Features

Germfree’s Class III Biosafety Cabinets are available with features and options that are designed and fitted to meet your exact needs. These include: Pass throughs/Airlocks, Through-wall Embeds, Stainless Steel Transport Containers, Chemical Dunk Tanks, Back-Up Power Systems, Single and Double-Sided Gloveports, Reachback Cameras and Monitors, Security Bars, NBC Filter Systems, HEPA Carbon Filters. Explore below:

  • Pass-throughs and airlocks can be virtually any size and can be equipped with the following:

     

    • Windows
    • Sliding Trays
    • Gloveports
    • Interlocks
    • HEPA Purge
    • Maximum of 4 doors
    • Piping and ports for independent decontamination
    • Chain of custody port
  • Through-wall embeds are equipped with seamless bioseals and gaskets to prevent the ingress and egress of contaminants into or out of the containment zone.

    Examples of Through-wall Embeds Include:

     

    • Class III BSC through-wall
    • RTPs (Rapid Transfer Ports)
    • Autoclaves
    • Airlocks
    • Chemical Dunk Tanks
  • The U.S. Army’s SCBCOM developed these transport containers to enable a first responder or field collector to safely and securely transport samples containing hazardous chemicals, potential chemical warfare agents, and infectious biological materials. These materials can then be transported from the point of collection to the Laboratory Response Network (LRN), Public Health Lab, or other facilities for analysis. Transport Containers utilize RTP technology to maintain sample containment during transport and transfer. The unit passes military and industrial hazardous sample container tests. Triple packaged samples are contained in a 60 ml primary container, placed in a 500 ml secondary container, and placed within the Stainless Steel Transport Container.

  • Chemical dunk tanks are available in a variety of configurations and materials.

     

    • Side mount with drain constructed of coated 316 stainless steel
    • Bottom mount with drain
    • Sliding bottom mount to conserve space
    • Dunk tanks are all-stainless steel coated with HALAR® or can be made from high density plastics or fiberglass

     

    Back-Up Power Supply

    A back-up power supply system is available for Class III Biosafety Cabinets. These systems are designed to supply necessary power for safe and proper shut-down of equipment in the event of a power failure.

    Gloveports (Single/Double-Sided)

    Based on the intended use, Germfree can equip the Class III BSC with round, oval or oversized oval gloveports and wide panel polycarbonate viewing screens on one or both sides.

  • We offer a range of biosecurity options, including:

     

    • Reachback Camera and Monitor for Enhanced Biosecurity
    • Security Bars for Class III Biosafety Cabinets
    • Glovebox Security Bars

     

    Cameras mounted inside Class III Biosafety Cabinets provide additional biosecurity. These allow additional viewers to witness manipulations while monitors inside the glovebox allow the user to review and adjust images prior to sending. The monitors also allow users to observe activity outside of the laboratory. All of the captured audio and video can be recorded internally or remotely to document chain of custody.

  • Designed originally for military mobile laboratory applications, the N.B.C. (Nuclear, Biological, and Chemical) filter system unit has been incorporated into Class III BSC for civilian first responders and public health laboratories.

    Air that is exhausted from the Class III BSC passes through an exhaust HEPA filter prior to reaching the N.B.C. Filter System Unit. The air then passes through an additional HEPA filter and two MIL Spec Carbon filters prior to discharge to the outside environment.

    The air sampling port located between the two Carbon filters is used to monitor any breakthrough from the first filter to determine whether both Carbon filters should be replaced during maintenance. A bubble-tight inlet and exhaust dampers allow for gas decontamination of the HEPA filter and housing prior to filter change. The filter unit is designed with a Bag-Out system for safe removal and disposal of the HEPA and Carbon filters.

    The N.B.C. (Nuclear, Biological, and Chemical) filtration system is designed for work in conjunction with the Class III Glovebox but can also be used with other containment equipment. It utilizes redundant HEPA and Carbon filters with a breakthrough monitor placed between the two carbon filters. If desired, the Carbon filters supplied can be Mil Spec ASZM-TEDA. Developed by the U.S. Army to handle chemical weapons, ASZM-TEDA carbon is activated and impregnated carbon specifically for this use.

Optional Integrations

Decontamination ports w RTP

Rapid Transfer
Port

Rapid Transfer Ports provide a fast method for safely moving specimens, materials, supplies and waste into and out of the Class III BSC without breaking containment. They are incorporated in the side walls of the Class III BSC-glovebox and are commonly used to transfer material between multiple gloveboxes. Rapid Transfer Ports can also be utilized to transfer hazardous waste to an autoclave.

Integrated Autoclaves and Sterilizers

Integrated Autoclaves & Sterilizers

Germfree offers seamless integration of our Class III BSC-glovebox to double door autoclaves to provide the highest level of hazardous waste decontamination and removal. Units are Factory Acceptance Tested (FAT) at our facility prior to shipment and validation packages can be provided.

decon

Environmental Test Chambers

Germfree’s Class III Biosafety Cabinets can be provided with programmable temperature & humidity control systems in order to match environmental conditions. The bulk of the mechanical equipment may be located outside of the containment zone for ease of service and maintenance.

Gas Decontamination

Gas
Decontamination

Germfree’s Class III Biosafety Cabinets can be provided with programmable temperature & humidity control systems in order to match environmental conditions. The bulk of the mechanical equipment may be located outside of the containment zone for ease of service and maintenance.

Past Germfree Projects

Germfree consistently delivers exceptional cGMP compliant products around the globe. Browse the grid below to see a selection of relevant past projects:

Mobile Hospital Compounding Pharmacy
Mobile
The remodeling of an I.V. pharmacy presents a range of potentially difficult or costly challenges. During building renovations it is imperative that compounding operations are not interrupted or otherwise negatively impacted
USA
Microbiome Research Modular Cleanroom
Biopharma Projects
This BSL 2+ cGMP Modular Biocontainment Cleanroom Facility is made up of five (5) prefabricated modules (2,000 ft2 / 184 m2 gross area) and is housed within a renovated warehouse structure. The cleanroom is designed to comply with FDA and EU cGMP standards and utilizes a unidirectional process flow.
Alachua, FL
Mobile Viral Vector Production Facility
Biopharma Projects
This Mobile BSL-3 Viral Vector Production Facility is based on quantity 2 semi-trailer chassis (840 ft2 / 79 m2 gross area) and functions as a mobile cGMP cleanroom to facilitate Viral Vector Manufacturing (VVM).
Maryland, USA

Let's build
your next
project.

It is the dedication of the Germfree team that enables rapid deployment of critical infrastructure both to cutting edge research facilities and the front lines of global health security