Application

Plasmids

Essential building blocks in plasmid production and the manufacturing of cell and gene therapies

Cleanrooms and Equipment Engineered for Plasmid Production and Research

Plasmid production depends on cleanroom controls that hold up through fermentation, where consistency determines yield. Instead, Germfree designs facilities around your process, your scale, and your risk profile, not a standard offering. Plasmid manufacturing underpins advanced therapies including gene therapy and mRNA vaccines, a fast growing corner of the biopharmaceutical industry. Germfree builds these facilities for the researchers and biopharmaceutical companies doing that work now.

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Facilities and Equipment for Plasmid Production

Platforms built for your process. Select from application ready layouts and equipment, or reach out to talk about a custom facility.

Mobile

bioGO^®: Mobile cGMP Cleanrooms for Plasmid Manufacturing

bioGO® is a cGMP Mobile Cleanroom trailer built for urgent plasmid manufacturing capacity needs, adaptable across fermentation, purification, and fill processes at a range of scales. We build it for clinical phase or point-of-care manufacturing, and back it with design, fabrication, validation, and maintenance services.

Germfree designs and operates this mobile platform to meet FDA cGMP requirements and industry best practices, giving plasmid manufacturers a flexible, compliant path to capacity when fermentation timelines can’t wait.

Learn more about our mobile facilities

Germfree has deployed more than 100 cGMP and USP 797/800 mobile cleanrooms globally since 2015
Built on a standard platform, configured to your fermentation and purification process, ISO 7/8 Grade B, C, and D
Supported by commissioning and qualification, 24/7 service, remote monitoring, and preventative maintenance
Biosafety cabinets, laminar flow hoods, passthroughs, gowning benches, and 100% stainless steel casework
Rapid deployment in weeks, not months, gets you to the clinic sooner
Available for sale or lease

Mobile cGMP Cleanrooms

Germfree’s Mobile cGMP Cleanroom platform supports aseptic processing needs with a flexible, rapidly deployable design.

Key applications:

Cell Therapy

Gene Therapy

Aseptic Filling

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Modular

Modular cGMP Cleanrooms for Plasmid Manufacturing

Germfree’s prefabricated cGMP Modular Cleanroom facilities support advanced therapy and pharmaceutical production processes, with layout options and mechanical space configurations for a free-standing facility or one inside a shell building. Design, project management, supply chain, commissioning and qualification, and maintenance are handled as one service, start to finish. Germfree’s modular cleanroom facilities are built for flexibility, reliability, and compliance in biopharmaceutical manufacturing.

Learn more about our modular facilities

Onsite in approximately 8 months for standard platforms
Compliant with US and EU cGMP, BSL2 and BSL3, ISPE Baseline Guides, and ISO 14644
Layout configurations built on standard platform technology
Construction built to reduce contamination risk
Commissioning and qualification, 24/7 service, remote monitoring, and preventative maintenance included
Available for sale or lease
Relocatable when manufacturing needs change

Modular cGMP Cleanrooms

Germfree cGMP Modular Cleanroom facilities support both cGMP and cGMP/BSL2 production.

Key applications:

Aseptic Filling

CGT Manufacturing

Viral Vectors

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Equipment

Innovative Aseptic Processing Equipment and PECs

Germfree’s standard and custom equipment line has been the foundation of the company for over 60 years. Our primary engineering controls (PECs) hold up under real use: 100% stainless steel, engineered for precise ergonomics, and built to handle both hazardous and non-hazardous materials, including the reagents and buffers plasmid purification depends on. Pharmaceutical isolators and restrictive access barriers, laminar flow workstations, biological safety cabinets (BSCs), compounding aseptic isolators (CAIs), compounding aseptic containment isolators (CACIs), powder hoods, and material passthroughs support fermentation, lysis, purification, and fill steps across the plasmid production process.

Learn more about our equipment

Standard biosafety cabinets and laminar flow equipment ship fast, supporting fermentation and downstream purification
NSF/ANSI49 options available
Touch control interface available on some models
100% 304 and 316L stainless steel construction
Modular facility integration
Built for cleanability and durability

All EQT- Biopharmaceutical Isolators & RABS EQT-Class II Type A2 BSC EQT-Class II Type B2 BSC EQT-Vertical Laminar Airflow Workstation EQT-Horizontal Laminar Airflow Workstation EQT - 100% Stainless Steel Casework EQT-Pass-Through

Pharmaceutical Isolators

Germfree designs and manufactures cGMP-compliant pharmaceutical isolators in the USA, protecting products, personnel, and laboratory processes.

Smarthood™

Smarthood™ is our innovative solution that integrates essential peripherals like touchscreen PCs, cameras, scales, and printers directly into a clean, clutter-free hood, enhancing aseptic technique and streamlining your workflow.

Stainless Steel Laboratory Furniture

Germfree's 100% stainless steel laboratory furniture resists corrosion, rust, and bacterial growth, custom designed for your lab or cleanroom.

Frequently Asked Questions

Explore additional insights

What cleanroom requirements apply to plasmid production?

Plasmid production requires stringent cleanroom controls to ensure successful fermentation processes and consistent, high-quality yields, supporting applications like gene therapy and mRNA vaccine manufacturing.

Does Germfree offer mobile cleanrooms for plasmid manufacturing?

Yes. The bioGO® cGMP Mobile Cleanroom trailer addresses urgent biopharma manufacturing capacity needs, supporting processes from cell therapy to sterile fill manufacturing, with rapid deployment in weeks rather than months.

What compliance standards do Germfree’s cleanrooms meet?

Germfree has deployed more than 100 cGMP and USP 797/800 mobile cleanrooms globally since 2015, and modular cleanroom facilities are compliant with US & EU cGMP, BSL2/BSL3, ISPE Baseline Guides, and ISO 14644.

Are modular cleanrooms available for plasmid manufacturing?

Yes. Germfree’s prefabricated cGMP Modular Cleanroom facilities support advanced therapy and pharmaceutical production processes, available as free-standing facilities or located in a shell building, and we offer them for sale or lease.

What equipment does Germfree offer for plasmid production processes?

Germfree’s equipment line includes pharmaceutical isolators, Restricted Access Barrier Systems, laminar flow workstations, biological safety cabinets, compounding aseptic isolators and containment isolators, powder hoods, and material pass throughs.

Can Germfree’s cleanroom facilities be relocated as manufacturing needs change?

Yes. Modular cGMP Cleanroom facilities are relocatable when manufacturing needs change.

Talk to us about the right solution for your application

When your mission calls for something custom, we deliver.

Some environments can’t take a catalog answer: the one-of-a-kind containment lab, the facility that has to survive shipment by military aircraft, the compounding pharmacy that has to stand up overnight. Tell us the constraints, we’ll build around them.

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